protein

IL-6R alpha Protein, Human (HEK293, Fc)

HY-P73222

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

35;55;150;255;1050;1800 USD

IL-6R alpha Protein, Human (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

35;55;150;255;1050;1800 USD

IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway [1] [2] . IL-6R alpha/CD126, Human consists of 468 amino acids (M1-R468) with two fibronectin type-III-like domains contained in the N-terminal part (113-217 a.a, 218-316 a.a), and a soluble form (1-365 a.a). Soluble IL-6R (sIL-6R) binds IL-6 and dimerized gp130 to achieve trans signaling, and exhibits a tissue expression property in some immune systems. IL-6R alpha Protein, Human (M1-P365) is soluble form and produced in HEK293 cells with a C-Terminal hFc-tag.

Human

IL-6 acts as both inflammatory factor and anti-inflammatory factor, fuels cancer progression through activating a series of downstream signalling cascade including gp130 (dimers), JAK/STAT, MAPK, and Akt [1] [2] . IL-6R alpha (IL-6Rα) as a part of the receptor for interleukin 6, is a type I transmembrane glycoprotein, which forms a complex with the type I transmembrane signal transducer Glycoprotein 130 (CD130) and regulates the biological activity of IL-6 with a low affinity [3] . The sequence of amino acids in IL-6R alpha proteins of human is very different from mouse (54.07%) and rat (54.68%). IL-6R alpha has 2 isoform including mIL6R (the longer one) or sIL6R (the shorter one): The mIL6R is membrane-bound interleukin-6 receptor, has the potential to drive naive CD4 + T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells [4] . The sIL-6R is soluble interleukin-6 receptor subunit, cleaved from IL-6R alpha (IL-6Rα) in activated CD4 + T cells by proteolysis, and serves as IL-6 agonist. sIL-6R binds membrane-bound IL6R and subunit IL6ST to activate regenerative and anti-inflammatory signal via IL-6 trans signaling and promotes pro-inflammatory properties of IL-6. The hydrolysis of IL-6R alpha is also called ectodomain shedding [1] . IL-6R alpha involves in regulating cell growth and differentiation, and plays an important role in regulation of immune response, acute-phase reactions and hematopoiesis [5] . However, IL-6R alpha shows tissue expression specificity in liver and some cells of the immune system, thus results a limitation of IL6 signaling [6] . It's worth noting that IL-6R alpha dysregulation is implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer [7] [8] .

Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; gp80; CD126

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.