protein

IL-34 Protein, Mouse (HEK293, His)

HY-P73212

50 μg

180 USD

IL-34 Protein, Mouse (HEK293, His)

proteins

HEK293

50 μg

180 USD

IL-34 protein is an important cytokine that promotes the proliferation, survival, and differentiation of monocytes and macrophages. It plays a key role in innate immune responses and inflammatory processes by promoting the release of pro-inflammatory chemokines. IL-34 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-34 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

Interleukin-34 (IL-34) is a cytokine with pivotal functions in innate immunity and inflammatory processes, as it promotes the proliferation, survival, and differentiation of monocytes and macrophages. Additionally, IL-34 plays a crucial role in the regulation of osteoclast proliferation and differentiation, influencing bone resorption. The cytokine's impact is mediated through its interaction with CSF1R, leading to the activation of downstream effectors and subsequent phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Structurally, IL-34 exists as a homodimer, and its intricate involvement in immune regulation and bone homeostasis highlights its significance in orchestrating cellular responses and maintaining tissue integrity.

Interleukin-34; IL-34; C16orf77

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 6.0, 8% trehalose.

Room temperature in continental US; may vary elsewhere.