product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
IL-21R Protein, Rat (HEK293, His)
catalog :
HY-P73191
quantity :
2 μg;10 μg;50 μg;100 μg;500 μg;1 mg
price :
30;72;185;300;780;1250 USD
more info or order :
product information
Catalog Number :
HY-P73191
Product Name :
IL-21R Protein, Rat (HEK293, His)
Product Type :
proteins
Host Species :
HEK293
Size :
2 μg;10 μg;50 μg;100 μg;500 μg;1 mg
List Price :
30;72;185;300;780;1250 USD
Product Description :
IL-21R Protein, a receptor for interleukin-21, is a type I cytokine receptor. It forms a heterodimer with the common gamma subunit and associates with Janus kinase 1 (JAK1). These interactions are pivotal for transducing the cellular responses initiated by interleukin-21, regulating immune processes and inflammatory pathways. IL-21R Protein, Rat (HEK293, His) is the recombinant rat-derived IL-21R protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-21R Protein, Rat (HEK293, His) is 217 a.a., with molecular weight of 32-50 kDa.
SpeciesSummary :
Rat
Background :
Interleukin 21 receptor (IL-21R), a receptor for interleukin-21, is a type I cytokine receptor. It forms a heterodimer with the common gamma subunit and associates with Janus kinase 1 (JAK1). Through this interaction, the receptor facilitates the signaling cascade initiated by interleukin-21, a cytokine with diverse immunoregulatory functions. The formation of the IL-21R heterodimer and its association with JAK1 are pivotal steps in transducing the cellular responses triggered by interleukin-21, contributing to the regulation of immune processes and inflammatory pathways. IL-21R is highly expressed in hematological malignancies and enhances the aggressiveness of follicular lymphoma. IL-21R results in the pathogenesis of leukemia and large cell lymphoma through activation of the JAK/STAT signaling pathway. The knockdown of IL-21R markedly suppressed GC cell proliferation and invasion, and IL-21R expression was further validated to be negatively regulated by miR-125a-3p (miR-125a). Moreover, it reduces the growth and invasion of NSCLC cells via inhibiting Wnt/β‑catenin signaling and PD‑L1 expression [1] [2] .
ALTnames :
Interleukin-21 receptor; IL-21 receptor; IL-21R; CD360; Nilr
Purity :
Greater than 95% as determined by reducing SDS-PAGE
Buffer :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Storage :
Room temperature in continental US; may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA