protein

IL-2 Protein, Canine (C147S)

HY-P73188

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;115;300;480;1440;2300 USD

IL-2 Protein, Canine (C147S)

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;115;300;480;1440;2300 USD

IL-2 Protein, produced by activated T-cells, NK cells, and helper T-cells, is crucial for immune response and tolerance. It binds to receptor complexes, activating signaling pathways. IL-2 Protein acts as a growth factor, enhances NK-cell activity, promotes B-cell proliferation, and regulates regulatory T-cells. It also participates in differentiating effector T-cell subsets and memory CD8-positive T-cells. IL-2 Protein, Canine (C147S) is the recombinant canine-derived IL-2 protein, expressed by E. coli , with tag free and C147S mutation.

Canine

IL-2 Protein, produced by activated CD4-positive helper T-cells and to a lesser extent activated CD8-positive T-cells and natural killer (NK) cells, plays vital roles in the immune response and tolerance. It binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122, and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG), leading to downstream signaling through phosphorylation of JAK1 and JAK3. This activation triggers various pathways, including STAT, phosphoinositide-3-kinase/PI3K, and mitogen-activated protein kinase/MAPK pathways. IL-2 Protein acts as a T-cell growth factor, enhancing NK-cell cytolytic activity, promoting the proliferation of activated B-cells, and stimulating immunoglobulin production. It also plays a crucial role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are essential for immune tolerance. Additionally, IL-2 Protein participates in the differentiation and homeostasis of effector T-cell subsets, such as Th1, Th2, Th17, and memory CD8-positive T-cells.

Interleukin-2; T-cell growth factor; TCGF

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween80.

Room temperature in continental US; may vary elsewhere.