protein

IL-17A Protein, Rhesus macaque (sf9)

HY-P73177

10 μg;50 μg;100 μg

100;250;400 USD

IL-17A Protein, Rhesus macaque (sf9)

proteins

Sf9 insect cells

10 μg;50 μg;100 μg

100;250;400 USD

IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases [1] [2] . IL-17A Protein, Rhesus macaque (sf9) is a recombinant rhesus macaque IL-17A protein and is expressed in sf9 insect cells.

Rhesus Macaque

Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4 + T cells. IL-17A is also produced by a wide variety of immune cells, including CD8 + T cells, γδT cells, natural killer T (NKT) cells, monocytes, and neutrophils [1] [2] [3] . The rhesus macaque IL-17A shares 96.77% amino acid sequence identity with human and 63.23% identity with mouse. IL-17A plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides (defensins and S100 proteins), cytokines (IL-6, G-CSF, and GM-CSF), chemokines (CXCL1, CXCL5, IL-8, CCL2, and CCL7), and matrix metalloproteinases (MMP1, MMP3, and MMP13). IL-17A is detrimental in viral infection through promoting neutrophilic inflammation. IL-17A is a homodimeric cytokine and shares similar biological activities with IL-17F. IL-17A binds to IL-17RA with high affinity, and IL-17RA is required for the biological activity of IL-17A. In tumorigenesis, IL-17A recruits myeloid derived suppressor cells (MDSCs) to dampen anti-tumor immunity. IL-17A also enhances tumor growth in vivo through the induction of IL-6 [1] [2] . IL-17A can be used for the research of autoimmune diseases, infection and cancer [1] [4] .

CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, pH 8.0, 10% Glycerol, 150 mM NaCl.

Shipping with dry ice