protein

IL-10 Protein, Human (HEK293, His)

HY-P73153

5 μg;10 μg;20 μg;50 μg

115;185;295;560 USD

IL-10 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;20 μg;50 μg

115;185;295;560 USD

IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293, His) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His labeled tag.

Human

IL-10 Protein, a key immune regulatory cytokine, exerts potent anti-inflammatory effects to prevent excessive tissue damage caused by inflammation. It engages its heterotetrameric receptor, composed of IL10RA and IL10RB, triggering JAK1 and STAT2-mediated phosphorylation of STAT3. This leads to STAT3 translocation into the nucleus, driving the expression of anti-inflammatory mediators. IL-10 Protein targets antigen-presenting cells like macrophages and monocytes, inhibiting the release of pro-inflammatory cytokines. It also hinders antigen presentation by reducing MHC-class II and co-stimulatory molecule expression, thereby dampening T cell activation. Additionally, it reprograms metabolic pathways, including mTOR signaling, to control the inflammatory response of macrophages. The protein forms homodimers and interacts with IL10RA and IL10RB.

Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b

Greater than 85% as determined by reducing SDS-PAGE

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4

Shipping with dry ice.