protein

IGFBP-6 Protein, Human (HEK293, His)

HY-P73141

10 μg;50 μg;100 μg

108;280;450 USD

IGFBP-6 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg;100 μg

108;280;450 USD

IGFBP-6 protein is an important IGFBP member that regulates insulin-like growth factor (IGF) by changing its interaction with cell surface receptors, thereby affecting IGF-induced growth responses. In addition to regulating IGF signaling, IGFBP-6 also activates the MAPK pathway and induces cell migration. IGFBP-6 Protein, Human (HEK293, His) is the recombinant human-derived IGFBP-6 protein, expressed by HEK293 , with C-His labeled tag.

Human

IGFBP-6 Protein, a member of the insulin-like growth factor-binding proteins (IGFBPs), assumes a pivotal role in regulating the half-life of insulin-like growth factors (IGFs) and modulating their effects on cell culture, exhibiting the ability to either inhibit or stimulate IGF-induced growth-promoting responses. This regulatory function is achieved through the alteration of IGFs' interaction with their respective cell surface receptors. Beyond its role in modulating IGF signaling, IGFBP-6 also exhibits additional cellular effects, such as the activation of the MAPK signaling pathway and the induction of cell migration. Notably, IGFBP-6 interacts with PHB2 via its C-terminal domain, highlighting its involvement in protein-protein interactions that may contribute to diverse cellular processes. The multifaceted actions of IGFBP-6 underscore its significance in orchestrating intricate cellular responses associated with growth, migration, and signaling pathways.

Insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IBP6

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice