protein

IFN-alpha 13/IFNA13 Protein, Mouse (HEK293, His)

HY-P73125

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

35;68;188;320;900;1520 USD

IFN-alpha 13/IFNA13 Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

35;68;188;320;900;1520 USD

IFN-alpha 13 (IFNA13), belongs to type I interferon family, is produced by macrophages with antiviral activities [1] . IFN-alpha 13/IFNA13 Protein, Mouse (HEK293, His) contains 189 a.a. (M1-E189), produced in HEK293 cells with a C-terminal His-tag.

Mouse

IFN-alpha 13 (IFNA13; IFN-α13) is produced by the macrophages, belongs to the alpha/beta interferon (IFN) family, a family of cytokines induced by viral infection and are primarily involved in antiviral defense of the cells [1] . Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia [3] . IFN-alpha13 exhibits acid-stable antiviral activity against Theiler's virus, Mengo virus, and vesicular stomatitis virus. Firstly, it is transcribed constitutively, independent of viral infection and of interferon regulatory factor-7 induction. Secondly, it contains two N-glycosylation sites, in contrast to other murine IFN-alpha subtypes that contain either one or no N-glycosylation site [4] . As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA13 protein of human is very different from mouse (64.55%)

Interferon alpha-13; IFN-alpha-13; LeIF D; IFNA13

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.