protein

B7-H2/ICOSLG Protein, Mouse (HEK293, His)

HY-P73120

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;67;190;320;1200;1700 USD

B7-H2/ICOSLG Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;67;190;320;1200;1700 USD

B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses. It acts as a costimulatory signal, promoting T and B cell proliferation, cytokine secretion, and plasma cell differentiation. B7-H2/ICOSLG Protein, Mouse (HEK293, His) is the recombinant mouse-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Mouse (HEK293, His) is 233 a.a., with molecular weight of ~40-52 kDa.

Mouse

B7-H2/ICOSLG, a ligand for the T-cell-specific surface receptor ICOS, serves as a crucial mediator of immune responses. This protein functions as a costimulatory signal, promoting T-cell proliferation and cytokine secretion while also inducing B-cell proliferation and differentiation into plasma cells. Beyond its role in immune activation, B7-H2/ICOSLG may play a pivotal role in mediating local tissue responses during inflammatory conditions. Furthermore, it contributes to the modulation of the secondary immune response by co-stimulating memory T-cell function. Notably, during pregnancy, B7-H2/ICOSLG may influence the cytokine profile of maternal T-cells, favoring an immunoprotective Th2 phenotype. Additionally, the interaction of B7-H2/ICOSLG with CTLA4 has been observed in vitro, highlighting its involvement in intricate regulatory pathways of immune function.

ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275

Greater than 95% as determined by reducing SDS-PAGE or Tris-Bis PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.