protein

VEGF164 Protein, Mouse

HY-P7312

10 μg;50 μg

220;620 USD

VEGF164 Protein, Mouse

proteins

E. coli

10 μg;50 μg

220;620 USD

377622443

VEGF164 Protein, Mouse is a potent mediator of angiogenesis and binds the semaphorin receptor, neuropilin1.

Mouse

VEGF164 was found to be significantly more potent at inducing inflammation. In vivo blockade of VEGF receptor (VEGFR)-1 significantly suppressed VEGF164-induced corneal inflammation. In vitro, VEGF164 more potently stimulated intracellular adhesion molecule (ICAM)-1 expression on endothelial cells, an effect that was mediated by VEGFR2. VEGF164 was also more potent at inducing the chemotaxis of monocytes, an effect that was mediated by VEGFR1. In an immortalized human leukocyte cell line, VEGF164 was found to induce tyrosine phosphorylation of VEGFR1 more efficiently [1] . VEGF164 is an important isoform in the pathogenesis of early diabetic retinopathy [2] .

VEGF-AA; rMuVEGF164; VPF

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4 or PBS, pH 6.5, 8% trehalose or 20 mM PB, 150 mM NaCl , pH 6.5, 8% trehalose.

Room temperature in continental US; may vary elsewhere.