protein

Galectin-1/LGALS1 Protein, Human

HY-P73072

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;72;185;300;1050;1900 USD

Galectin-1/LGALS1 Protein, Human

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;72;185;300;1050;1900 USD

Galectin-1/LGALS1 is a lectin that binds β-galactoside and complex carbohydrates and regulates apoptosis, proliferation, and differentiation. It inhibits CD45 phosphatase activity, blocks Lyn kinase dephosphorylation, and induces T cell apoptosis. Galectin-1/LGALS1 Protein, Human is the recombinant human-derived Galectin-1/LGALS1 protein, expressed by E. coli , with tag free.

Human

The Galectin-1/LGALS1 protein serves as a lectin with the ability to bind beta-galactoside and a diverse range of complex carbohydrates. It plays a pivotal role in the regulation of apoptosis, cell proliferation, and cell differentiation. Galectin-1/LGALS1 exerts its influence by inhibiting the protein phosphatase activity of CD45, consequently impeding the dephosphorylation of Lyn kinase. Additionally, it acts as a potent inducer of T-cell apoptosis. Existing as a homodimer, Galectin-1/LGALS1 forms interactions with a variety of cellular entities, including CD2, CD3, CD4, CD6, CD7, CD43, ALCAM, and CD45. It also binds LGALS3BP, laminin (via poly-N-acetyllactosamine), and SUSD2. Notably, Galectin-1/LGALS1 engages in an interaction with the cargo receptor TMED10, facilitating translocation from the cytoplasm into the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and subsequent secretion.

Galectin-1; Gal-1; HLBP14; Galaptin; HBL; LGALS1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.