protein

TRAIL/TNFSF10 Protein, Human (N-His)

HY-P7306A

2 μg;10 μg;50 μg;100 μg;500 μg

30;60;135;225;532 USD

TRAIL/TNFSF10 Protein, Human (N-His)

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;500 μg

30;60;135;225;532 USD

TRAIL/TNFSF10 protein is a cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly TNFRSF11B/OPG. It induces apoptosis, a process that can be mediated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG, which lack the ability to induce apoptosis. TRAIL/TNFSF10 Protein, Human (N-His) is the recombinant human-derived TRAIL/TNFSF10 protein, expressed by E. coli , with N-6*His labeled tag. The total length of TRAIL/TNFSF10 Protein, Human (N-His) is 168 a.a., with molecular weight of ~22 kDa.

Human

TRAIL/TNFSF10 protein, a cytokine, binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly TNFRSF11B/OPG. It induces apoptosis, a process that may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG, which lack the ability to induce apoptosis. Existing as a homotrimer, one TNFSF10 homotrimer interacts with three TNFSF10A monomers, and similarly, one TNFSF10 homotrimer interacts with three TNFSF10B monomers. This intricate interaction underlines the complexity of TRAIL/TNFSF10-mediated apoptotic signaling, showcasing its ability to engage multiple receptors and form distinct molecular configurations for its biological activity.

rHuTRAIL/Apo2L; TNFSF10; CD253

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.