protein

Fumarate Hydratase/FH Protein, Human (His)

HY-P73062

5 μg;10 μg;50 μg

48;82;230 USD

Fumarate Hydratase/FH Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

48;82;230 USD

The fumarate hydratase/FH protein plays a key role in cellular processes as it catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle, which is essential for energy production through the production of NADH . Fumarate Hydratase/FH Protein, Human (His) is the recombinant human-derived Fumarate Hydratase/FH protein, expressed by E. coli , with C-His labeled tag. The total length of Fumarate Hydratase/FH Protein, Human (His) is 466 a.a., with molecular weight of ~50 kDa.

Human

Fumarate Hydratase (FH) is an enzyme that catalyzes the reversible conversion of fumarate to L-malate. This stereospecific interconversion plays a pivotal role in the tricarboxylic acid (TCA) cycle, a central metabolic pathway involved in energy production. Specifically, FH facilitates the hydration of fumarate to L-malate, contributing to a key transition step in the TCA cycle. Experiments in various species suggest that specific isoforms of FH may act in defined pathways and exhibit preferences for one direction of the reaction over the other. By participating in the TCA cycle, FH ensures the efficient generation of energy in the form of NADH, highlighting its essential role in cellular metabolism.

Fumarate Hydratase; Fumarase; HsFH; FH

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris, 5 mM EDTA, 1 mM DTT, pH 8.0.

Room temperature in continental US; may vary elsewhere.