protein

FGFR-4 Protein, Human (HEK293, Fc)

HY-P73057

2 μg;10 μg;50 μg

41;115;320 USD

FGFR-4 Protein, Human (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg

41;115;320 USD

The leptin R/LEPR protein is a receptor protein that binds to the hormone leptin. It plays a vital role in regulating energy balance and body weight. FGFR-4 Protein, Human (HEK293, Fc) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-4 Protein, Human (HEK293, Fc) is 348 a.a., with molecular weight of 95-112 kDa.

Human

The FGFR-4 Protein serves as a tyrosine kinase and cell surface receptor for fibroblast growth factors, playing a pivotal role in regulating multiple pathways, including cell proliferation, differentiation, migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. Structurally, the protein comprises an extracellular region with three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. Through its extracellular portion, which interacts with fibroblast growth factors, FGFR-4 initiates downstream signaling cascades that ultimately influence mitogenesis and differentiation. The gene demonstrates broad expression, with elevated levels observed in the lung (RPKM 16.7), kidney (RPKM 12.5), and 15 other tissues, underscoring its potential significance in diverse physiological contexts across various organs.

Fibroblast growth factor receptor 4; FGFR-4; CD334; JTK2; TKF

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Room temperature in continental US; may vary elsewhere.