protein

EphB4 Protein, Mouse (HEK293, His)

HY-P73005

2 μg;10 μg;50 μg;100 μg

30;55;120;190 USD

EphB4 Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

30;55;120;190 USD

Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

Ephb4 Protein, a receptor tyrosine kinase, exhibits promiscuous binding to transmembrane ephrin-B ligands on neighboring cells, initiating contact-dependent bidirectional signaling. This leads to both forward signaling, downstream of the receptor, and reverse signaling, downstream of the ephrin ligand. Crucially, Ephb4 Protein, in conjunction with its cognate ligand EFNB2, regulates cell adhesion and migration, playing a pivotal role in heart morphogenesis, angiogenesis, blood vessel remodeling, and permeability. Notably, EPHB4-mediated forward signaling governs cellular repulsion and segregation from EFNB2-expressing cells.

Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.