protein

EphB4 Protein, Mouse (HEK293, Fc)

HY-P73004

10 μg;50 μg;100 μg

80;200;300 USD

EphB4 Protein, Mouse (HEK293, Fc)

proteins

HEK293

10 μg;50 μg;100 μg

80;200;300 USD

Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag.

Mouse

Ephb4 Protein, a receptor tyrosine kinase, exhibits promiscuous binding to transmembrane ephrin-B ligands on neighboring cells, initiating contact-dependent bidirectional signaling. This leads to both forward signaling, downstream of the receptor, and reverse signaling, downstream of the ephrin ligand. Crucially, Ephb4 Protein, in conjunction with its cognate ligand EFNB2, regulates cell adhesion and migration, playing a pivotal role in heart morphogenesis, angiogenesis, blood vessel remodeling, and permeability. Notably, EPHB4-mediated forward signaling governs cellular repulsion and segregation from EFNB2-expressing cells.

Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 7.5.

Shipping with dry ice