protein

DKK-1 Protein, Mouse (HEK293, His)

HY-P72969

5 μg;10 μg;50 μg;100 μg

58;100;280;475 USD

DKK-1 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

58;100;280;475 USD

DKK-1 protein antagonizes canonical Wnt signaling by inhibiting LRP5/6-Wnt interaction and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization. In addition to its Wnt-dependent role, DKK1 has Wnt-independent anti-apoptotic activity by inhibiting the pro-apoptotic function of KREMEN1. DKK-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DKK1 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

DKK1 protein serves as a potent antagonist of canonical Wnt signaling through multiple mechanisms, including inhibiting the interaction between LRP5/6 and Wnt and forming a ternary complex with the transmembrane protein KREMEN, which facilitates the internalization of LRP5/6. Additionally, DKK1 exhibits Wnt-independent anti-apoptotic activity by inhibiting the pro-apoptotic function of KREMEN1. In limb development, DKK1 plays a crucial role by attenuating Wnt signaling, contributing to normal limb patterning. The protein's interactions with LRP5, LRP6, and KREM1, especially in the presence of MESD, highlight its involvement in the intricate regulation of Wnt-mediated signaling pathways, underscoring its significance in various cellular processes and developmental contexts.

Dickkopf-related protein 1; Dickkopf-1; Dkk-1; SK; DKK1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 (Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.) or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.