protein

Cystatin B/CSTB Protein, Human (His)

HY-P72965

5 μg;10 μg;50 μg;100 μg

40;65;180;300 USD

Cystatin B/CSTB Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

40;65;180;300 USD

Cystatin B (CSTB) Protein is a member of the cystatin family. Cystatin B/CSTB Protein, Human (His) is the recombinant human-derived Cystatin B/CSTB protein, expressed by E. coli , with N-His labeled tag. The total length of Cystatin B/CSTB Protein, Human (His) is 97 a.a., with molecular weight of ~15 kDa.

Human

Cystatin B/CSTB Protein functions as an intracellular thiol protease inhibitor. Cystatin B/CSTB protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin B/CSTB protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in Cystatin B/CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens.

Cystatin B; CSTB; Stefin B; EPM1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 50 mM NaCl, pH 8.0 or 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.