protein

COMP Protein, Human (HEK293, His)

HY-P72945

50 μg;100 μg

485;825 USD

COMP Protein, Human (HEK293, His)

proteins

HEK293

50 μg;100 μg

485;825 USD

The COMP protein is critical for cartilage integrity and interacts with extracellular matrix proteins to promote the connection of chondrocytes to the cartilage matrix through integrin receptors. Its role in the pathogenesis of osteoarthritis emphasizes the significance of joint health. COMP Protein, Human (HEK293, His) is the recombinant human-derived COMP protein, expressed by HEK293 , with C-His labeled tag. The total length of COMP Protein, Human (HEK293, His) is 737 a.a., with molecular weight of 120-130 kDa.

Human

The COMP protein assumes a crucial role in preserving the structural integrity of cartilage by interacting with other extracellular matrix proteins, including collagens and fibronectin. It facilitates the connection between chondrocytes and the cartilage extracellular matrix by engaging with cell surface integrin receptors. Additionally, COMP's involvement in the pathogenesis of osteoarthritis underscores its potential significance in joint health. Beyond its structural role, COMP emerges as a potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Its anti-apoptotic effects are mediated by inhibiting caspase-3 activation and inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5, and XIAP). Furthermore, COMP plays an essential role in maintaining the contractile and differentiated phenotype of vascular smooth muscle cells under both physiological and pathological stimuli, achieved through its interaction with ITGA7. This multifaceted functionality positions COMP as a key player in the maintenance of cartilage structure, joint health, and cellular survival processes.

Cartilage oligomeric matrix protein; COMP; Thrombospondin-5; TSP5

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.