protein

HGFR Protein, Canine (HEK293, His)

HY-P72934

2 μg;10 μg;50 μg;100 μg

35;60;165;280 USD

HGFR Protein, Canine (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

35;60;165;280 USD

The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Canine (HEK293, His) is the recombinant canine-derived HGFR protein, expressed by HEK293 , with N-His labeled tag. The total length of HGFR Protein, Canine (HEK293, His) is 911 a.a., with molecular weight of ~35-43 kDa & 80-100 kDa, respectively.

Canine

The HGFR protein, a receptor tyrosine kinase, serves as a critical transducer of signals from the extracellular matrix by binding to hepatocyte growth factor/HGF ligand. It plays a pivotal role in regulating various physiological processes, including proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding at the cell surface, MET undergoes autophosphorylation on its intracellular domain, creating docking sites for downstream signaling molecules. Upon activation, HGFR interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3, or the adapter GAB1, leading to the activation of multiple signaling cascades, such as RAS-ERK, PI3 kinase-AKT, and PLCgamma-PKC. RAS-ERK activation is associated with morphogenetic effects, while PI3K/AKT coordinates prosurvival effects. In embryonic development, HGFR signaling contributes to gastrulation, muscle and neuronal precursor development and migration, angiogenesis, and kidney formation. In adults, it participates in wound healing, organ regeneration, tissue remodeling, and promotes the differentiation and proliferation of hematopoietic cells. Additionally, in the context of microbial infection, HGFR acts as a receptor for Listeria monocytogenes internalin InlB, facilitating the entry of the pathogen into cells.

Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.