protein

CD74 Protein, Human (HEK293, His)

HY-P72931

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

CD74 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

CD74 is a key component of the class II major histocompatibility complex and serves as a key chaperone in antigen presentation in the regulation of immune responses. It doubles as a cell surface receptor for macrophage migration inhibitory factor (MIF), initiating survival pathways and cell proliferation. CD74 Protein, Human (HEK293, His) is the recombinant human-derived CD74 protein, expressed by HEK293 , with N-His labeled tag. The total length of CD74 Protein, Human (HEK293, His) is 160 a.a., with molecular weight of 30-40 kDa.

Human

The CD74 Protein plays a crucial role as an associate of class II major histocompatibility complex (MHC), functioning as a vital chaperone in the regulation of antigen presentation for immune response. Additionally, it serves as a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF), initiating survival pathways and cell proliferation upon binding. Notably, CD74 interacts with amyloid precursor protein (APP) and acts to suppress the production of amyloid beta (Abeta), implicating its potential role in neuroprotective mechanisms. The gene exhibits broad expression, with significant levels detected in spleen (RPKM 1835.3), lymph node (RPKM 1421.7), and 24 other tissues, highlighting its involvement in diverse immune and cellular processes across various organs.

HLA class II histocompatibility antigen gamma chain; CD74; CLIP; DHLAG

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.