protein

ICAM-3/CD50 Protein, Human (HEK293, His)

HY-P72921

5 μg;10 μg;50 μg;100 μg

45;75;200;340 USD

ICAM-3/CD50 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

45;75;200;340 USD

The ICAM-3/CD50 protein acts as a ligand for the leukocyte adhesion protein LFA-1 and integrin α-D/β-2, suggesting involvement in cell adhesion. ICAM-3 cooperates with integrin α-L/β-2 to facilitate phagocytosis of apoptotic neutrophils, suggesting a role in immune response regulation and apoptotic cell clearance. ICAM-3/CD50 Protein, Human (HEK293, His) is the recombinant human-derived ICAM-3/CD50 protein, expressed by HEK293 , with C-His labeled tag. The total length of ICAM-3/CD50 Protein, Human (HEK293, His) is 456 a.a., with molecular weight of 100-120 kDa.

Human

ICAM-3/CD50 Protein serves as a ligand for the leukocyte adhesion proteins LFA-1 (integrin alpha-L/beta-2) and integrin alpha-D/beta-2, implicating its involvement in cellular adhesion processes. When associated with integrin alpha-L/beta-2, ICAM-3 plays a contributory role in apoptotic neutrophil phagocytosis by macrophages, suggesting a potential role in the regulation of immune responses and clearance of apoptotic cells. Additionally, ICAM-3 interacts with moesin/MSN, indicating its participation in protein-protein interactions that may influence cellular signaling or structural organization. The multifaceted interactions of ICAM-3 underscore its significance in the intricate network of cellular adhesion and immune-related processes.

Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R; CD50

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.5 or pH 7.4.

Room temperature in continental US; may vary elsewhere.