protein

CD45 Protein, Mouse (HEK293, Fc)

HY-P72916

5 μg;10 μg;50 μg;100 μg

45;70;180;290 USD

CD45 Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

45;70;180;290 USD

The CD45 protein is a multifunctional member of the protein tyrosine phosphatase family with heparan sulfate proteoglycan and heparin binding activity as well as protein tyrosine phosphatase activity. It plays a crucial role in lymphocyte differentiation, macromolecular metabolic processes, and signal transduction regulation. CD45 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD45 protein, expressed by HEK293 , with C-hFc labeled tag.

Mouse

CD45 protein, a member of the protein tyrosine phosphatase family, exhibits versatile functions, including heparan sulfate proteoglycan binding activity, heparin binding activity, and protein tyrosine phosphatase activity. It is intricately involved in key processes such as lymphocyte differentiation, positive regulation of macromolecule metabolic processes, and regulation of signal transduction. CD45 acts upstream in lymphocyte-related pathways, including differentiation and activation, while being prominently located in the external side of the plasma membrane, focal adhesion, and membrane raft. Widely expressed in various structures such as the 3rd branchial arch, alimentary system, cardiovascular system, hemolymphoid system, and placenta, CD45's significance is underscored by its association with conditions like systemic lupus erythematosus. The human ortholog of this gene, PTPRC (protein tyrosine phosphatase receptor type C), is implicated in hepatitis C, multiple sclerosis, and severe combined immunodeficiency, highlighting its pivotal role in immune-related disorders.

Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45

Greater than 95% as determined by reducing SDS-PAGE or Tris-Bis PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.