protein

CD45 Protein, Mouse (sf9)

HY-P72914

10 μg;50 μg;100 μg

100;280;450 USD

CD45 Protein, Mouse (sf9)

proteins

Sf9 insect cells

10 μg;50 μg;100 μg

100;280;450 USD

CD45 Protein, a versatile member of the protein tyrosine phosphatase family, displays heparan sulfate proteoglycan and heparin binding activity, as well as protein tyrosine phosphatase activity. It plays a crucial role in lymphocyte differentiation, macromolecule metabolic processes, and signal transduction regulation. CD45 is associated with diseases such as systemic lupus erythematosus, hepatitis C, multiple sclerosis, and severe combined immunodeficiency. CD45 Protein, Mouse (sf9) is the recombinant mouse-derived CD45 protein, expressed by Sf9 insect cells , with tag free.

Mouse

Receptor-type tyrosine-protein phosphatase C (CD45), a member of the protein tyrosine phosphatase family, exhibits versatile functions, including heparan sulfate proteoglycan binding activity, heparin binding activity, and protein tyrosine phosphatase activity. It is intricately involved in key processes such as lymphocyte differentiation, positive regulation of macromolecule metabolic processes, and regulation of signal transduction. CD45 acts upstream in lymphocyte-related pathways, including differentiation and activation, while being prominently located in the external side of the plasma membrane, focal adhesion, and membrane raft. Widely expressed in various structures such as the 3rd branchial arch, alimentary system, cardiovascular system, hemolymphoid system, and placenta, CD45's significance is underscored by its association with conditions like systemic lupus erythematosus. The human ortholog of this gene, PTPRC (protein tyrosine phosphatase receptor type C), is implicated in hepatitis C, multiple sclerosis, and severe combined immunodeficiency, highlighting its pivotal role in immune-related disorders [1] [2] [3] .

Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45

Greater than 85% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% glycerol, 3 mM DTT, pH 7.5.

Shipping with dry ice