protein

CD4 Protein, Rat (HEK293, His)

HY-P72905

5 μg;10 μg

70;120 USD

CD4 Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg

70;120 USD

CD4 Protein is expressed on the surface of helper T cells.It plays a key role in immune responses by binding to major histocompatibility complex class II molecules on antigen-presenting cells, facilitating T cell activation and cytokine production.CD4 Protein is also involved in immune regulation and tolerance.Understanding its functions can aid in developing therapies for autoimmune diseases and immunodeficiencies.CD4 Protein, Rat (HEK293, His) is the recombinant rat-derived CD4 protein, expressed by HEK293 , with C-His labeled tag.

Rat

CD4, an integral membrane glycoprotein, plays a crucial role in orchestrating immune responses against external and internal threats. Primarily functioning as a coreceptor for MHC class II molecule:peptide complexes in T-cells, CD4 facilitates the recognition of antigens derived from extracellular proteins. Interacting simultaneously with the T-cell receptor (TCR) and MHC class II on antigen-presenting cells (APCs), CD4 recruits the Src kinase LCK to the TCR-CD3 complex, initiating intracellular signaling pathways that culminate in lymphokine production, cellular motility, adhesion, and activation of T-helper cells. Beyond T-cells, CD4 contributes to differentiation, activation, cytokine expression, and cell migration in macrophages or NK cells through a TCR/LCK-independent pathway. It also plays a role in the thymic development of T-helper cells and triggers the differentiation of monocytes into functional mature macrophages. The protein forms disulfide-linked homodimers on the cell surface and interacts with LCK, PTK2/FAK1, P4HB/PDI, and IL16. Additionally, CD4 binds to MHCII alpha and beta chains, enhancing the affinity of TCR for peptide-MHCII and facilitating adhesion between T cells and APCs through CD4 oligomerization.

T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.