protein

Carbonic Anhydrase 4 Protein, Human (HEK293, His)

HY-P72862

20 μg

340 USD

Carbonic Anhydrase 4 Protein, Human (HEK293, His)

proteins

HEK293

20 μg

340 USD

Carbonic anhydrase 4 catalyzes the reversible hydration of carbon dioxide and plays a crucial role in maintaining intracellular and extracellular pH. Carbonic Anhydrase 4 Protein, Human (HEK293, His) is the recombinant human-derived Carbonic Anhydrase 4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Carbonic Anhydrase 4 Protein, Human (HEK293, His) is 265 a.a., with molecular weight of ~30 kDa.

Human

Carbonic Anhydrase 4 (CA4) serves a crucial role in cellular physiology by catalyzing the reversible hydration of carbon dioxide into bicarbonate and protons, a process essential for maintaining intracellular and extracellular pH balance. This enzymatic activity, documented across various studies, underscores its significance in pH homeostasis. CA4 may additionally play a role in stimulating the sodium/bicarbonate transporter activity of SLC4A4, contributing to pH regulation. Particularly noteworthy is its essential function in removing acid overload from the retina and retina epithelium, as well as facilitating acid release in the choriocapillaris within the choroid. The multifaceted role of CA4 highlights its indispensable contribution to maintaining cellular pH homeostasis and underscores its relevance in various physiological processes.

Carbonic anhydrase 4; Carbonate dehydratase IV; CA-IV; CA4

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.