protein

BMP-2 Protein, Zebrafish

HY-P72854

20 μg;100 μg

304;850 USD

BMP-2 Protein, Zebrafish

proteins

E. coli

20 μg;100 μg

304;850 USD

Bone morphogenetic protein 2 (BMP-2) is a pleiotropic ligand protein belonging to TGFβ family, and is involved in key embryonic development of vascular and valvular homeostasis. BMP-2 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to regulate various types of calcification, including atherosclerosis, chronic kidney disease, diabetes, and valve calcification [1] . BMP-2 is overexpressed by myofibroblast and preosteoblast in the calcified area of human calcified valve, which are densely infiltrated by B lymphocytes and T lymphocytes [5] . BMP-2 is the junction between atherosclerotic vascular calcification and normal bone formation mechanism [6] . Zebrafish BMP-2 Protein has a length of 386 a.a., BMP-2 Protein, Zebrafish is 105 a.a. (Q272-R386), expressed in E. coli cells with tag free.

Others

Bone Morphogenetic Protein 2 (BMP-2) is a ligand protein with pleiotropic, belongs to TGFβ family. BMP-2 formats BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development [1] . BMP-2/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms [2] . BMP-2 is widely found in different animals, while the sequence in human is similar to rat (91.86%), and mouse (92.13%). BMPs exhibits critical contributions to the pathophysiology of atherosclerosis, pulmonary vascular disease, and vascular and valvular calcification [1] . BMP-2 binds different receptor, such as type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A), to regulate various calcification type including Atherosclerosis, Chronic Kidney Disease, Diabetes, Valvular Calcification [1] . BMP-2 promotes monocyte infiltration and inflammation of atherosclerotic legions [3] . It is linked to increased plaque formation via pro-inflammatory and pro-atherogenic effects, promoting oxidative stress, endothelial dysfunction and osteogenic differentiation [4] . BMP-2 is overexpressed in ossified regions of human calcified valves by myofibroblasts and pre-osteoblasts in areas densely infiltrated with B- and T-lymphocytes [5] . And it serves as the linkers between atherosclerotic vascular calcification with mechanisms of normal bone formation [6] . BMP-2 induces angiogenesis, endothelial cells (ECs) proliferation, and migration [7] . And BMP-2 also enhances the expression of the osteoblast and chondrocyte master transcriptional regulator RUNX2 to promote the mineralization of cultured human coronary vascular SMCs in a manner that was dependent on oxidative stress and endoplasmic reticulum (ER) stress [8] .

BDA2; BMP-2; BMP-2A; Bone morphogenetic protein 2a; SSFSC

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 30 mM HAC, pH 3.0 or 50 mM Tris-HCL, 300 mM NaCl, 200 mM Arginine, pH 8.0.

Room temperature in continental US; may vary elsewhere.