protein

BACE1 Protein, Mouse (HEK293, His)

HY-P72843

5 μg;10 μg;50 μg;100 μg;500 μg

45;75;205;350;1050 USD

BACE1 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

45;75;205;350;1050 USD

BACE1 protein is an important member of the peptidase A1 family and is involved in the pathogenesis of Alzheimer's disease.They produce mature proteases through proteolytic processing of preprotein, which catalyze the initial steps in the formation of amyloid beta peptide from the amyloid precursor protein.BACE1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BACE1 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

BACE1, a member of the peptidase A1 family of aspartic proteases, plays a pivotal role in the pathogenesis of Alzheimer's disease. This gene gives rise to multiple transcript variants, one of which encodes a preproprotein undergoing proteolytic processing to generate the mature protease. Functioning as a transmembrane protease, BACE1 catalyzes the initial step in the formation of amyloid beta peptides from amyloid precursor protein. These peptides constitute the primary components of amyloid beta plaques, prominent in the brains of individuals with Alzheimer's disease. Homozygous knockout mice for BACE1 display a spectrum of nervous system defects, growth retardation, metabolic abnormalities, and elevated neonatal lethality. The broad expression of BACE1 across various tissues, including the cerebellum and ovary, underscores its significance beyond the central nervous system.

Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.