protein

Angiopoietin-2 Protein, Mouse (HEK293, His)

HY-P72830

50 μg

350 USD

Angiopoietin-2 Protein, Mouse (HEK293, His)

proteins

HEK293

50 μg

350 USD

Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of Angiopoietin-2 Protein, Mouse (HEK293, His) is 222 a.a., with molecular weight of ~33.4 kDa.

Mouse

Angiopoietin-2 Protein (ANGPT2) binds to TEK/TIE2 and competes with ANGPT1 for the binding site, thereby modulating ANGPT1 signaling. It has the ability to induce tyrosine phosphorylation of TEK/TIE2 even in the absence of ANGPT1. In the absence of angiogenic inducers like VEGF, ANGPT2 can cause loosening of cell-matrix contacts, potentially leading to endothelial cell apoptosis and subsequent vascular regression. However, when working in conjunction with VEGF, it can promote endothelial cell migration and proliferation, making it a permissive angiogenic signal. ANGPT2 also plays a role in the regulation of lymphangiogenesis. Additionally, it interacts with TEK/TIE2, competing for the same binding site as ANGPT1, and interacts with ITGA5.

Angiopoietin-2; ANG-2; ANGPT2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.