protein

ADAM17/TACE Protein, Rat (HEK293, His)

HY-P72815

2 μg;10 μg;50 μg;100 μg

80;225;630;1070 USD

ADAM17/TACE Protein, Rat (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

80;225;630;1070 USD

ADAM17/TACE Protein, a pivotal enzyme, cleaves TNF-alpha and activates various cell-surface proteins like p75 TNF-receptor. It also mediates the cleavage of Notch, activates the Notch pathway, and contributes to hemostasis by shedding GP1BA. ADAM17/TACE further facilitates the cleavage of LAG3, IL6R, and FCGR3A, showcasing its significance in diverse cellular functions. ADAM17/TACE Protein, Rat (HEK293, His) is the recombinant rat-derived ADAM17/TACE protein, expressed by HEK293 , with C-10*His labeled tag. The total length of ADAM17/TACE Protein, Rat (HEK293, His) is 546 a.a., with molecular weight of 57 & 20 kDa, respectively.

Rat

ADAM17, also known as TACE, serves as a pivotal enzyme in diverse cellular processes, notably cleaving the membrane-bound precursor of TNF-alpha to its mature soluble form. Beyond its role in TNF-alpha processing, ADAM17 exhibits a broad substrate specificity, orchestrating the proteolytic release of various cell-surface proteins such as p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein. Moreover, ADAM17 acts as an activator of the Notch pathway by mediating the cleavage of Notch, generating the membrane-associated intermediate fragment known as Notch extracellular truncation (NEXT). Its involvement extends to hemostasis through shedding the platelet glycoprotein Ib alpha chain (GP1BA) and mediating the cleavage of LAG3, IL6R, and FCGR3A, highlighting its significance in diverse cellular functions.

Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; CD156b; Tace

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.