protein

ACE2 Protein, Rat (HEK293, His)

HY-P72809

5 μg;10 μg;50 μg;100 μg

68;115;325;550 USD

ACE2 Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

68;115;325;550 USD

ACE2 is an important carboxypeptidase in the renin-angiotensin system that complexly regulates cardiovascular homeostasis. It specifically converts angiotensin I to angiotensin 1-9 and angiotensin II to angiotensin 1-7, exerting antihypertrophic and vasodilatory effects. ACE2 Protein, Rat (HEK293, His) is the recombinant rat-derived ACE2 protein, expressed by HEK293 , with C-His labeled tag. The total length of ACE2 Protein, Rat (HEK293, His) is 723 a.a., with molecular weight of 105-120 kDa.

Rat

ACE2, an essential counter-regulatory carboxypeptidase within the renin-angiotensin hormone system, stands as a pivotal regulator orchestrating blood volume, systemic vascular resistance, and overall cardiovascular homeostasis. This multifunctional enzyme displays remarkable specificity in its actions, converting angiotensin I to angiotensin 1-9 and angiotensin II to angiotensin 1-7. These biologically active peptides exhibit anti-hypertrophic effects in cardiomyocytes and act as beneficial vasodilators, counteracting the vasoconstrictor properties of angiotensin II. Beyond its role in the angiotensin system, ACE2 demonstrates versatility by cleaving various vasoactive peptides, including neurotensin, kinetensin, and des-Arg bradykinin. Notably, ACE2 is intricately involved in amino acid transport, serving as a binding partner for the amino acid transporter SLC6A19 in the intestine. Through its involvement in trafficking, surface expression, and catalytic activity modulation, ACE2 plays a crucial role in the regulation of amino acid transport processes.

Angiotensin-converting enzyme 2; ACE-2; ACEH; ACE-related carboxypeptidase

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.