protein

FGF-13 Protein, Human

HY-P72803

10 μg;50 μg

100;300 USD

FGF-13 Protein, Human

proteins

E. coli

10 μg;50 μg

100;300 USD

FGF-13 protein is a microtubule-binding protein that directly binds and stabilizes tubulin and affects microtubule polymerization. It exerts negative regulation on axonal and leading process branches, which are critical for neuronal polarization and migration in the cerebral cortex and hippocampus. FGF-13 Protein, Human is the recombinant human-derived FGF-13 protein, expressed by E. coli , with tag free. The total length of FGF-13 Protein, Human is 245 a.a., with molecular weight of ~27.6 kDa.

Human

FGF-13, a microtubule-binding protein, exerts direct interaction with tubulin, participating in both the polymerization and stabilization of microtubules. This engagement in microtubule dynamics suggests a role in the refinement of axons by negatively regulating branching of axonal and leading processes. Additionally, FGF-13 plays a crucial role in the polarization and migration of neurons within the cerebral cortex and hippocampus. It further regulates voltage-gated sodium channel transport and function, influencing the activity of specific sodium channel isoforms. Beyond its microtubule-related functions, FGF-13 is implicated in the development of axonal initial segment-targeting inhibitory GABAergic synapses facilitated by chandelier neurons. Through its diverse interactions, including those with various sodium channels and MAPK signaling components, FGF-13 emerges as a multifaceted player in the intricate regulatory network governing neuronal processes and synaptic functions.

Fibroblast growth factor 13; FGF-13; FHF-2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, pH 8.5, 500 mM NaCl.

Room temperature in continental US; may vary elsewhere.