protein

HA/Hemagglutinin Protein, H1N1 (sf9, His)

HY-P72800

10 μg

145 USD

HA/Hemagglutinin Protein, H1N1 (sf9, His)

proteins

Sf9 insect cells

10 μg

145 USD

HA/hemagglutinin proteins bind to sialic acid receptors and initiate viral attachment and internalization through clathrin-dependent or -independent pathways. This class I viral fusion protein determines viral host range and virulence. HA/Hemagglutinin Protein, H1N1 (sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of HA/Hemagglutinin Protein, H1N1 (sf9, His) is 529 a.a., with molecular weight of ~66 kDa.

Virus

Binds to sialic acid-containing receptors on the cell surface, facilitating the attachment of the virus particle. This attachment leads to the internalization of the virion through either clathrin-dependent endocytosis or a clathrin- and caveolin-independent pathway. HA/Hemagglutinin Protein plays a crucial role in determining the host range restriction and virulence of the virus. It acts as a Class I viral fusion protein, enabling the penetration of the virus into the cell cytoplasm by mediating the fusion of the endocytosed virus particle's membrane with the endosomal membrane. The acidic pH in endosomes triggers a conformational change in HA2, causing the release of the fusion hydrophobic peptide. Multiple trimers are necessary to form a functional fusion pore.

Hemagglutinin; HA; Influenza A virus (strain swl A/California/04/2009 H1N1)

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, pH 7.4, 300 mM NaCl, 5% mannitol, 5% trehalose.

Room temperature in continental US; may vary elsewhere.