product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
Histone H3 Protein, Human (His)
catalog :
HY-P72798
quantity :
5 μg;10 μg;50 μg
price :
100;170;475 USD
product information
Catalog Number :
HY-P72798
Product Name :
Histone H3 Protein, Human (His)
Product Type :
proteins
Host Species :
E. coli
Size :
5 μg;10 μg;50 μg
List Price :
100;170;475 USD
Product Description :
Histone H3 proteins are critical in nucleosomes, which compact DNA into chromatin and regulate DNA accessibility. Histone H3 Protein, Human (His) is the recombinant human-derived Histone H3 protein, expressed by E. coli , with N-His labeled tag. The total length of Histone H3 Protein, Human (His) is 136 a.a., with molecular weight of ~16.8 kDa.
SpeciesSummary :
Human
Background :
Histone H3, a fundamental component of the nucleosome, serves as a linchpin in the intricate process of wrapping and compacting DNA into chromatin, which in turn restricts DNA accessibility to cellular machineries requiring DNA as a template. This histone, alongside its counterparts, assumes a pivotal role in pivotal cellular functions, including transcription regulation, DNA repair, DNA replication, and the maintenance of chromosomal stability. The regulation of DNA accessibility involves a sophisticated interplay of post-translational modifications collectively referred to as the histone code, coupled with the dynamic remodeling of nucleosomes. The nucleosome itself comprises a histone octamer, composed of two molecules each of H2A, H2B, H3, and H4, assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. This octamer efficiently wraps approximately 147 base pairs of DNA, exemplifying its indispensable role in organizing chromatin structure and facilitating crucial genomic processes. Additionally, Histone H3 interacts with various cellular components such as TONSL, CHAF1A, CHAF1B, MCM2, and DNAJC9, further contributing to its multifaceted functions.
ALTnames :
Histone H3.1; Histone H3
Purity :
Greater than 90% as determined by reducing SDS-PAGE.
Buffer :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.
Storage :
Room temperature in continental US; may vary elsewhere.
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com
609-228-6898
headquarters: USA