protein

IFN-alpha 1b/IFNA13 Protein, Human

HY-P72796

10 μg;50 μg;100 μg

140;400;680 USD

IFN-alpha 1b/IFNA13 Protein, Human

proteins

E. coli

10 μg;50 μg;100 μg

140;400;680 USD

IFN-alpha 1/13 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities [1] . IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway [4] , exerts function by inhibiting viral replication as well as modulating immune response [3] . IFN-alpha 1b/IFNA13 Protein, Human contains 166 a.a. (C24-D189, A137V), produced in E. coli cells with tag free.

Human

Interferon alpha-1/13 is produced by the macrophages, belongs to the alpha/beta interferon (IFN) family, a family of cytokines induced by viral infection and are primarily involved in antiviral defense of the cells [1] . Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia [3] . IFN-alpha13 exhibits acid-stable antiviral activity against Theiler's virus, Mengo virus, and vesicular stomatitis virus. Firstly, it is transcribed constitutively, independent of viral infection and of interferon regulatory factor-7 induction. Secondly, it contains two N-glycosylation sites, in contrast to other murine IFN-alpha subtypes that contain either one or no N-glycosylation site [4] . As for a wildly use of IFN in animal model, the sequence of amino acids in IFNA13 protein of human is very different from mouse (64.55%)

Interferon alpha-1/13; IFN-alpha-1/13; LeIF D; IFNA1; IFNA13

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, containing 4% mannitol and 1% HSA.

Room temperature in continental US; may vary elsewhere.