protein

RSPO1/R-spondin-1 Protein, Human (HEK293, His)

HY-P72784

2 μg;10 μg;50 μg;100 μg

45;125;350;600 USD

RSPO1/R-spondin-1 Protein, Human (HEK293, His)

Protein

HEK293

2 μg;10 μg;50 μg;100 μg

45;125;350;600 USD

RSPO1/R-spondin-1 is a secreted glycoprotein. RSPO1/R-spondin-1 binds to LGR4/5/6 receptors and ZNRF3/E3 ubiquitin ligases, inhibits Wnt receptor degradation, stabilizes β-catenin and promotes its nuclear translocation, and activates target gene transcription. RSPO1/R-spondin-1, Human promotes intestinal organoid survival, induces pancreatic β-cell proliferation to improve diabetes, enhances osteogenic differentiation of mesenchymal stem cells to treat osteoporosis, and inhibits bone erosion in arthritis models. RSPO1/R-spondin-1 Protein, Human (HEK293, His) is a recombinant RSPO1/R-spondin-1 protein expressed by HEK293 with a C-His tag.