protein

B7-2/CD86 Protein, Rabbit (HEK293, His)

HY-P72766

10 μg;50 μg

120;250 USD

B7-2/CD86 Protein, Rabbit (HEK293, His)

proteins

HEK293

10 μg;50 μg

120;250 USD

The B7-2/CD86 protein is a key receptor that provides costimulatory signals critical for T lymphocyte proliferation and interleukin-2 production through CD28 or CTLA-4 binding. It plays a decisive role in early T cell activation, affecting immunity or anergy within 24 hours. B7-2/CD86 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived B7-2/CD86 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of B7-2/CD86 Protein, Rabbit (HEK293, His) is 224 a.a., with molecular weight of 39-67 kDa.

Rabbit

B7-2/CD86 Protein functions as a receptor pivotal for the costimulatory signal necessary for T-lymphocyte proliferation and interleukin-2 production, achieved by binding to CD28 or CTLA-4. It plays a crucial role in the early events of T-cell activation and costimulation of naive T-cells, contributing to the decision between immunity and anergy within 24 hours after activation. Additionally, B7-2/CD86 participates in the regulation of B cell function, influencing the level of IgG(1) produced. Upon CD40 engagement, it activates the NF-kappa-B signaling pathway through phospholipase C and protein kinase C activation. The protein forms homodimers and interacts with MARCH8. Furthermore, it engages with PHB1 and PHB2, with the interactions intensifying after priming with CD40.

T-lymphocyte activation antigen CD86; Activation B7-2 antigen; CD86

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.