protein

MIP-4/CCL18 Protein, Human (His)

HY-P72759

2 μg;10 μg;50 μg;100 μg;500 μg

40;115;320;545;1300 USD

MIP-4/CCL18 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;500 μg

40;115;320;545;1300 USD

MIP-4/CCL18 Protein, Human (His) is a CC chemokine ligand that binds to PITPNM3, GPR30 and CCR8 receptors and also acts as a neutral CCR3 antagonist mediating inflammation, autoimmunity and carcinogenesis. MIP-4/CCL18 Protein, Human (His) is a recombinant human MIP-4/CCL18 (A21-A89) protein expressed by E. coli with a his tag at N end [1] [2] .

Human

CCL18, also known as macrophage inflammatory protein-4 (MIP-4), pulmonary and activation-regulated chemokine (PARC), dendritic cell (DC)-chemokine 1 (DC-CK1) and alternative macrophage activation-associated CC chemokine-1 (AMAC-1), is a small cell factor of the CC chemokine family. CCL18 is located on chromosome 17 in the human gene and has the highest amino acid identity (65%) with CCL3, encoding an 89 amino acid long protein with a 20 amino acid long peptide signal sequence at the N' terminus that signals its secretion and is cleaved in the endoplasmic reticulum into a 69 amino acid long mature protein [1] . CCL18 is mainly produced by antigen-presenting cells of the innate immune system, including dendritic cells, monocytes and macrophages, but not in T and B cells. In macrophages, CCL18 is induced by the Th2 cytokines IL-4 and IL-13, which program macrophages to differentiate into AAMs, which contribute to the healing phase of acute inflammatory responses and to tissue remodeling and fibrosis in chronic inflammatory diseases.CCL18 can bind to PITPNM3, GPR30, and CCR8 receptors, where CCL18 binding to CCR8 binding induces chemotaxis of Th2 cells. In addition, CCL18 can also act as a neutral CCR3 antagonist and participate in the inflammatory response. It has been shown that CCL18 and its receptor CCR8 are co-expressed in diseased human tissues during active eosinophilic inflammation. In parallel, enhanced production of CCL18 has been demonstrated in a variety of diseases, including various malignancies and inflammatory joint, lung and skin diseases [2] .

C-C motif chemokine 18; AMAC-1; DC-CK1; MIP-4; CCL18; PARC; SCYA18

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Citrate, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 4.0 or 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

Room temperature in continental US; may vary elsewhere.