protein

Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His)

HY-P72735

10 μg;50 μg

152;400 USD

Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

152;400 USD

Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and is involved in a variety of effector and regulatory functions. When co-aggregated with BCR, TCR and Fc receptors, it promotes endocytosis of soluble immune complexes (IIB2), modulates antibody production, and downregulates B-cell, T-cell and mast cell activation. Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His) is the recombinant mouse-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-6*His labeled tag.

Mouse

Fc gamma RIIB/CD32b Protein functions as a receptor for the Fc region of complexed immunoglobulins gamma, exhibiting low affinity. It plays a role in various effector and regulatory functions, including the phagocytosis of antigen-antibody complexes from the circulation and the modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but do not mediate endocytosis or phagocytosis, while isoform IIB2 can facilitate the endocytosis of soluble immune complexes via clathrin-coated pits. Both isoform IIB1 and isoform IIB2 can down-regulate the activation of B-cells, T-cells, and mast cells when coaggregated with B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively. Fc gamma RIIB/CD32b interacts with FGR and LYN (By similarity).

Low affinity immunoglobulin gamma Fc region receptor II; Fc-gamma-RIIB; Ly-17; CD32; Fcgr2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.