protein

CD46 Protein, Human (HEK293, His)

HY-P72723

10 μg;50 μg

128;360 USD

CD46 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

128;360 USD

CD46 protein is an important cofactor for complement factor I, a serine protease that protects autologous cells by cleaving deposited C3b and C4b. In addition to complement regulation, CD46 is involved in sperm-oocyte fusion during fertilization. CD46 Protein, Human (HEK293, His) is the recombinant human-derived CD46 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD46 Protein, Human (HEK293, His) is 294 a.a., with molecular weight of 50-65 kDa.

Human

CD46 protein serves as a crucial cofactor for complement factor I, a serine protease responsible for safeguarding autologous cells against complement-mediated damage by cleaving deposited C3b and C4b on host tissue. Beyond its role in complement regulation, CD46 is implicated in the fusion process between spermatozoa and oocytes during fertilization. Additionally, CD46 acts as a costimulatory factor for T-cells, facilitating the differentiation of CD4+ cells into T-regulatory 1 cells. These specialized T-regulatory 1 cells contribute to immune modulation by secreting interleukin-10, thereby playing a pivotal role in suppressing immune responses and preventing autoimmunity.

Membrane Cofactor Protein; TLX; CD46; MCP; MIC10

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.