protein

CD5L Protein, Mouse (HEK293, His)

HY-P72717

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;65;180;305;1100;1600 USD

CD5L Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;65;180;305;1100;1600 USD

The CD5L protein is primarily expressed by macrophages and regulates inflammatory responses in infection or atherosclerosis. CD5L is incorporated into adipocytes via CD36-mediated endocytosis, thereby inhibiting lipid droplet size and affecting lipolysis. CD5L Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD5L protein, expressed by HEK293 , with C-6*His labeled tag.

Mouse

CD5L Protein serves as a pivotal regulator of lipid synthesis, predominantly expressed by macrophages in lymphoid and inflamed tissues, orchestrating inflammatory responses in conditions such as infection or atherosclerosis. Its impact extends to adipocytes, where it inhibits lipid droplet size and influences lipolysis following incorporation into mature adipocytes through CD36-mediated endocytosis. By associating with cytosolic FASN, CD5L suppresses fatty acid synthase activity, resulting in the breakdown of triacylglycerols into glycerol and free fatty acids. In the context of obesity, CD5L-induced lipolysis contributes to inflammation and insulin resistance by recruiting inflammatory macrophages into adipose tissues. Additionally, CD5L exerts regulatory control over metabolic pathways in T-helper Th17 cells, influencing the expression of pro-inflammatory genes by modulating lipid content and limiting the synthesis of cholesterol ligands for RORC, the master transcription factor of Th17-cell differentiation. Notably present in non-pathogenic Th17 cells, CD5L alters polyunsaturated fatty acyl content, affecting metabolic proteins and consequently limiting RORC activity. Moreover, CD5L plays a role in obesity-associated autoimmunity by associating with IgM, interfering with Fcalpha/mu receptor binding, and enhancing the development of long-lived plasma cells producing high-affinity IgG autoantibodies. Beyond its metabolic functions, CD5L acts as an apoptosis inhibitor in macrophages, promoting their survival against the apoptotic effects of oxidized lipids in atherosclerosis. Furthermore, it contributes to the early response to microbial infection, serving as a pattern recognition receptor and promoting autophagy. CD5L's multifaceted roles underscore its significance in diverse physiological processes and its potential implications in various pathological conditions.

CD5 antigen-like; mAIM; SP-alpha; Cd5l; AIM; API6

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.