protein

DDR2 Protein, Mouse (HEK293, His)

HY-P72673

10 μg;50 μg

120;288 USD

DDR2 Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

120;288 USD

The DDR2 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that critically regulates cell differentiation, extracellular matrix remodeling, migration, and proliferation.DDR2 is crucial for bone development.It affects osteoblast differentiation and chondrocyte maturation through the MAP kinase signaling pathway and activates the transcription factor RUNX2.DDR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR2 protein, expressed by HEK293 , with C-6*His labeled tag.

Mouse

DDR2 protein serves as a tyrosine kinase functioning as a cell surface receptor for fibrillar collagen, pivotal in regulating cell differentiation, extracellular matrix remodeling, cell migration, and cell proliferation. Its role is essential for normal bone development, influencing osteoblast differentiation and chondrocyte maturation through a signaling pathway involving MAP kinases, ultimately activating the transcription factor RUNX2. DDR2 also plays a crucial part in extracellular matrix remodeling by up-regulating collagenases MMP1, MMP2, and MMP13, facilitating cell migration and promoting tumor cell invasion. Additionally, DDR2 promotes fibroblast migration and proliferation, contributing significantly to the process of cutaneous wound healing. The multifaceted functions of DDR2 underscore its importance in diverse cellular processes associated with tissue development, maintenance, and repair.

Discoidin domain-containing receptor 2; CD167b; Ddr2; Ntrkr3; Tkt; Tyro10

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.