protein

Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His)

HY-P72628

10 μg;50 μg

95;250 USD

Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

10 μg;50 μg

95;250 USD

GPC3 is a member of the heparan sulfate proteoglycans (HSPGs), and attaches to the cell surface by a glycosylphosphatidylinositol anchor. GPC3 is overexpressed in hepatocellular carcinoma (HCC) and can be used as a tumor marker for HCC. Membrane GPC3 can interact with several growth factors to promote the binding of growth factors to their receptors. GPC3 can form a complex with Wnt and activates Wnt signaling, leading to the HCC growth. In addition, GPC3 is also involved in the pathogenesis of Simpson-Golabi-Behmel overgrowth syndrome, regulates cell growth, regulates embryonic and fetal development [1] [2] [3] . Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His) is the recombinant Cynomolgus-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His) is 535 a.a., with molecular weight of 38 & 65-120 kDa, respectively.

Cynomolgus

GPC3 is a member of the heparan sulfate proteoglycans (HSPGs), and attaches to the cell surface by a glycosylphosphatidylinositol anchor. GPC3 is overexpressed in hepatocellular carcinoma (HCC) and can be used as a tumor marker for HCC. GPC3 plays a role in liver carcinogenesis [1] . Specifically, Membrane GPC3 can interact with several growth factors (eg: Wnt, Hedgehogs, bone morphogenetic factors, and FGF) to promote the binding of growth factors to their receptors. GPC3 can form a complex with Wnt and activates Wnt signaling, leading to the HCC growth [2] . In addition, GPC3 can regulate cell growth. GPC3 is highly expressed in mesodermal embryonic tissues, and the deletion of the GPC3 gene is involved in the pathogenesis of Simpson-Golabi-Behmel overgrowth syndrome. The interaction of GPC3 with IGF2 can reduce IGF2-mediated growth in vivo , which indicates that GPC3 negatively regulates embryonic and fetal development. Besides, GPC3 is a negative transcriptional regulator and tumor suppressor that inhibits the growth of breast, ovary, and lung cancer cells [2] [3] . GPC3 has a cleavage site between Arg358 and Ser359, and can be cleaved by Furin protease [2] .

Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.