protein

IGFBP-1 Protein, Human (HEK293, His)

HY-P72608

10 μg;50 μg

130;365 USD

IGFBP-1 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

130;365 USD

IGFBP-1 protein extends the half-life of IGFs and modulates their activity. It can inhibit or stimulate IGFs' growth-promoting effects, altering their interaction with receptors and fine-tuning signaling pathways. IGFBP-1 promotes cell migration and binds to both IGF1 and IGF2, highlighting its versatile role in modulating IGF signaling pathways. IGFBP-1 Protein, Human (HEK293, His) is the recombinant human-derived IGFBP-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IGFBP-1 Protein, Human (HEK293, His) is 234 a.a., with molecular weight of 30-35 kDa.

Human

IGFBP-1 protein assumes a crucial role in modulating the activity of insulin-like growth factors (IGFs) by extending their half-life. With a dual regulatory influence in cell culture, IGFBP-1 can either inhibit or stimulate the growth-promoting effects of IGFs, highlighting its versatile impact on cellular processes. Additionally, IGFBP-1 is involved in altering the interaction between IGFs and their cell surface receptors, contributing to the fine-tuning of signaling pathways associated with IGF-mediated cellular responses. Notably, IGFBP-1 promotes cell migration, underscoring its broader involvement in cellular dynamics. Importantly, it exhibits an equal affinity for binding to both IGF1 and IGF2, indicating its ability to interact with multiple IGF isoforms and emphasizing the complexity of IGFBP-1's role in modulating IGF signaling pathways.

Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.