protein

MPIF-1/CCL23 Protein, Human (99a.a, CHO)

HY-P7259

2 μg;10 μg;50 μg;100 μg

50;130;390;660 USD

MPIF-1/CCL23 Protein, Human (99a.a, CHO)

proteins

CHO

2 μg;10 μg;50 μg;100 μg

50;130;390;660 USD

377622393

MPIF-1/CCL23 protein, Human (99a.a, CHO), a CC chemokine, is highly chemotactic for resting T cells and monocytes, mediates inflammatory and immune responses by binding to the chemokine receptor CCR1, inhibits myeloid progenitor cell formation, and has some pro-cancer effects. MPIF-1/CCL23 Protein, Human (99a.a, CHO) is a recombinant human MPIF-1/CCL23 (R22-N120) protein expressed by CHO [1] .

Human

CCL23, also known as macrophage inflammatory protein 3 (MIP-3) and myeloid progenitor inhibitory factor 1 (MPIF-1), is a small cytokine of the CC chemokine family, identified in 1997 in a cDNA library derived from human aortic endothelial cells and located on human chromosome 17. ccl23 has some amino acid similarity to ccl15 and is the only chemokine with an alternative splice variant in which the amino-terminal amino acid is deleted. Due to selective splicing, CCL23 occurs in two forms, the shorter CCL23α/CKβ8 and the longer CCL23β/CKβ8-1. CCL23 is expressed in liver, lung, pancreas and bone marrow tissues and is released by the constitutive type of monocyte-derived dendritic cells. ccl23 acts as a chemokine and is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. ccl23 functions primarily in combination with the chemokine receptor CCR1, a transmembrane G protein-coupled receptor. CCL23 has been reported to have dose-dependent inhibitory activity against progenitors of the granulocyte and monocyte producing lineages in mouse and human bone marrow stem cell colony formation assays in vitro. In addition, CCL23 plays a role in bone formation and is a potent chemoattractant for osteoblast precursors but has no effect on fully differentiated osteoblasts or osteoclasts. ccl23 has some pro-oncogenic effects and induces angiogenesis by activating CCR1 on vascular endothelial cells [1] [4] .

rHuMIP-3/CCL23; C-C motif chemokine 23; MPIF-1; SCYA23

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.