protein

IL-17B Protein, Human (HEK293, Fc)

HY-P72588

10 μg;50 μg

85;240 USD

IL-17B Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

85;240 USD

IL-17B is a proinflammatory cytokine and stimulates the release of tumour necrosis factor alpha (TNFα) and IL-1β. IL-17B plays an important role in cancer progression, angiogenesis, and inflammatory arthritis [1] [2] . IL-17B Protein, Human (HEK293, Fc) is a recombinant human IL-17B protein with hFc tag at the C-terminus and is expressed in HEK293 cells.

Human

Interleukin-17B (IL-17B) belongs to the IL-17 cytokine family and is a proinflammatory cytokine. IL-17B is expressed in adult pancreas, small intestine, stomach, spinal cord and testis [1] . The human IL-17B shares 88.33% amino acid sequence identity with mouse. IL-17B is secreted as a non-covalent dimer glycoprotein. IL-17B shares about 27% amino acid identity with IL-17A and stimulates the release of tumour necrosis factor alpha (TNFα) and IL-1β in the THP-1 monocytic cell line. The receptor of IL-17B is IL-17RB, which belongs to the IL-17 receptor family. IL-17B shares IL-17RB with IL-17E. IL-17B inhibits IL-17E binding to IL-17RA/IL-17RB complexes, exhibits protumor roles and IL-17E antitumor activities [1] [2] . IL-17B plays an important role in cancer progression, angiogenesis, and inflammatory arthritis [1] .

Interleukin-17B; IL-17B; Cytokine Zcyto7; IL-20; NIRF; ZCYTO7

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.