protein

IL-17C Protein, Human (HEK293, His)

HY-P72587

10 μg;50 μg

145;378 USD

IL-17C Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

145;378 USD

IL-17C is an early response cytokine in the defense against bacterial pathogens and upregulates the expression of a variety of antimicrobial peptides. IL-17C stimulates the release of cytokines and is implicated in autoimmune disorders and bacterial infections [1] . IL-17C Protein, Human (HEK293, His) is a recombinant human IL-17C protein with His tag at the C-terminus and is expressed in HEK293 cells.

Human

Interleukin-17C (IL-17C) belongs to the IL-17 cytokine family. IL-17C is predominantly expressed by epithelial cells. Human and mouse IL-17C shares 76.68% sequence identity. IL-17C binds to its functional receptor, a heterodimer formed by IL-17RA and IL-17RE. TLR2, TLR3 and TLR5 upregulate the expression of IL-17C at mucosal surfaces. The expression of IL-17C is also regulated by cytokines (TNF-α, IL-1β and IL-17A). IL-17C is an early response cytokine in the defense against bacterial pathogens and upregulates the expression of a variety of antimicrobial peptides including human beta-defensin 2 (hBD2), Lipocalin 2 (LCN2), and granzyme B. IL-17C also stimulates the release of cytokines (IL-1β, TNF-α, and IL-6). IL-17C is implicated in autoimmune disorders and bacterial infections [1] .

CX2; Cytokine CX2; IL17C; Interleukin-17C

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM NaAc, 50 mM NaCl, 6% Trehalose, 2%Mannitol, 0.05% Tween 80, pH 5.0.

Room temperature in continental US; may vary elsewhere.