protein

IL-18BP Protein, Human (HEK293, hFc)

HY-P72575

2 μg;5 μg;10 μg;50 μg;100 μg;500 μg

30;46;60;120;168;435 USD

IL-18BP Protein, Human (HEK293, hFc)

proteins

HEK293

2 μg;5 μg;10 μg;50 μg;100 μg;500 μg

30;46;60;120;168;435 USD

IL-18BP Protein belongs to immunoglobulin superfamily that bind to IL-18 and inhibits its activity. IL-18BP Protein functions as an inhibitor of the Th1 cytokine response [1] . IL-18BP Protein, Human (HEK293, hFc) is the recombinant human-derived IL-18BP protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-18BP Protein, Human (HEK293, hFc) is 164 a.a., with molecular weight of 55-80 kDa.

Human

IL-18BP Protein is a cytokine receptor that inhibits the binding of IL-18 to its receptor, and thus inhibits IL-18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses [1] . IL-18BP Protein is constitutively expressed and secreted in mononuclear cells [2] . Elevated level of IL-18BP Protein is detected in the intestinal tissues of patients with Crohn's disease [3] .

Interleukin-18-binding protein; IL-18BP; Tadekinig-alfa

Greater than 95% as determined by reducing SDS-PAGE or Tris-Bis PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.