product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
IL-20R beta Protein, Human (HEK293, Fc)
catalog :
HY-P72561
quantity :
10 μg;50 μg
price :
90;250 USD
more info or order :
product information
Catalog Number :
HY-P72561
Product Name :
IL-20R beta Protein, Human (HEK293, Fc)
Product Type :
proteins
Host Species :
HEK293
Size :
10 μg;50 μg
List Price :
90;250 USD
Product Description :
IL-20R beta Protein (IL20RB) is the beta subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway [1] . The IL-20RA/IL-20RB dimer is a receptor for IL-19, IL-20 and IL-24. The IL-22RA1/IL-20RB dimer is a receptor for IL-20 and IL-24 [2] . IL-20R beta Protein is consists of 308 amino acids (M1-S311) with a transmembrane domain (230-254 a.a.). IL-20R beta Protein, Cynomolgus (HEK293, His) is fibronectin type-III domain-containing protein, produced in HEK293 cells with a C-Terminal His-tag.
SpeciesSummary :
Human
Background :
IL-20R beta (IL-12RB), also known as a beta subunit of IL-20 receptor (IL-20RB), belongs to the type II cytokine receptor family. IL-20R beta is widely expressed with highest levels in skin and testis and highly expressed in psoriatic skin [1] .
IL-20R beta forms functional heterodimers with different subunit protein. IL-20R beta serves as the receptor for IL-19, IL-20 and IL-24 by dimerizing with IL20RA, however serves as the receptor for IL-20 and IL-24 by dimerizing with IL-22RA1 [2] .
IL-20RB/IL-20RA and IL-20RB/IL-22RA1, act function by binding IL-20, and then stimulates a signal transduction pathway through STAT3 in a keratinocyte cell line [1] .
However, the expression of both IL-20RB/IL-20RA is found to be upregulated in psoriatic skin lesions on keratinocytes [3] .
IL-20RB/IL-20RA and IL-20RB/IL-22RA1 bind to IL-24, induce rapid activation of Stat-1 and Stat-3 transcription factors, which appear to play a role in cell survival and proliferation [4] .
The sequence of amino acids in IL-12 beta proteins of human is very different from mouse (64.64%).
ALTnames :
Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Buffer :
Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
Storage :
Shipping with dry ice
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA