protein

IL-23R Protein, Mouse (HEK293, Fc)

HY-P72556

5 μg;10 μg;50 μg;100 μg;500 μg

62;100;250;400;1250 USD

IL-23R Protein, Mouse (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

62;100;250;400;1250 USD

IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-23R Protein, Mouse (HEK293, Fc) is 349 a.a., with molecular weight of 90-110 kDa.

Mouse

The IL-23R Protein forms the interleukin-23 receptor in association with IL12RB1. Acting as a binding site for IL23, this receptor mediates stimulation in T-cells, NK cells, and possibly certain macrophage/myeloid cells, likely through the activation of the Jak-Stat signaling cascade. IL-23R plays a crucial role in both innate and adaptive immunity and may contribute to the acute response to infection in peripheral tissues. Additionally, IL-23R has been implicated in autoimmune inflammatory diseases and is thought to be significant in tumorigenesis. Operating as a heterodimer with IL12RB1, the IL-23R complex, when exposed to IL23, forms the functional IL23 receptor. Furthermore, IL-23R interacts with JAK2 and, in the presence of IL23, associates with STAT3, contributing to downstream signaling processes (By similarity).

Interleukin-23 receptor; Il23r; IL-23 receptor

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.